#Common side effect of metformin full#

pain, tenderness, redness, or swelling of the area between the anus and genitals.

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position.large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals.difficult, burning, or painful urination.change in the color, amount, or odor of vaginal discharge.Although not all of these side effects may occur, if they do occur they may need medical attention.Ĭheck with your doctor immediately if any of the following side effects occur while taking dapagliflozin / metformin: More common

Serious side effects of Xigduo XRĪlong with its needed effects, dapagliflozin / metformin may cause some unwanted effects.

#Common side effect of metformin full#

Metformin-associated lactic acidosis was characterized by elevated blood lactate levels (greater than 5 mmol/Liter), anion gap acidosis (without evidence of ketonuria or ketonemia), an increased lactate/pyruvate ratio and metformin plasma levels generally greater than 5 mcg/mL.Risk factors for metformin-associated lactic acidosis include renal impairment, concomitant use of certain drugs (eg, carbonic anhydrase inhibitors such as topiramate), age 65 years old or greater, having a radiological study with contrast, surgery and other procedures, hypoxic states (eg, acute congestive heart failure), excessive alcohol intake, and hepatic impairment.Steps to reduce the risk of and manage metformin-associated lactic acidosis in these high risk groups are provided in the full prescribing information.If metformin-associated lactic acidosis is suspected, immediately discontinue dapagliflozin/metformin hydrochloride and institute general supportive measures in a hospital setting. The onset of metformin-associated lactic acidosis is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, somnolence, and abdominal pain. Lactic AcidosisPostmarketing cases of metformin-associated lactic acidosis have resulted in death, hypothermia, hypotension, and resistant bradyarrhythmias.